bk-mdma/methylone

ILOVE@LLGRLzZ

stimulant.

Tolerance to many of the effects of methylone develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 1 - 3 weeks for the tolerance to be reduced to half and 3 - 6 weeks to be back at baseline (in the absence of further consumption). Methylone presents cross-tolerance with all dopaminergic stimulants, meaning that after the consumption of methylone all stimulants will have a reduced effect.

Methylone was first synthesized by chemists Peyton Jacob III and Alexander Shulgin in 1996 as a potential antidepressant.^[1]

Methylone is sometimes used as a substitute for MDMA due to similarities in their effects. Alexander Shulgin commented that the substances has "almost the same potency of MDMA, but it does not produce the same effects." He also stated that it "has an almost antidepressant action, pleasant and positive, but not the unique magic of MDMA."^[2]

4-FMA 

stimulant

- The stimulation which 4-FMA presents can be described as being a mix between a typical entactogen stimulation and the stimulation style of Methamphetamine.

6-apb

MDA

stimulant

The potent agonism of the 5-HT_2B receptor makes it likely that 6-APB would be cardiotoxic with chronic or long-term use, as seen with other 5-HT_2B receptor agonists such as the withdrawn serotonergic anorectic fenfluramine.^[4][8]

The monoamine neurotransmitters known as serotonin, dopamine and noradrenaline are the global neurotransmitters that modulate the brain's ability to feel pleasure, motivation, reward, planning, attention, and focus. When their reuptake is inhibited or their release is promoted, these neurotransmitters accumulate in the synaptic cleft (gaps between neurons) to non-ordinary levels, which makes them able to be reused. The result is neuronal activation at a multitude of brain regions which has the net result of producing a combination of stimulating, relaxing, disinhibiting and euphoric effects.^[9]